Reactive oxygen species (ROS) and Embryonic stem cells
Reactive oxygen species (ROS) play a key role in aging and the development of age-associated diseases. Yet ROS have also a variety of crucial physiological functions, from the host defense to participation in biosynthetic processes from intracellular signaling to regulation of gene expression. We are particularly interested in the NOX family of NADPH oxidases. Members of this enzyme family are found in virtually all tissues of our organism, where they contribute to redox-dependent physiological processes, but also pathophysiologically relevant oxidative stress.
Embryonic stem cells are multipotent stem cells with a major potential for basic science and for clinical applications. We are particularly interested in the neuronal differentiation of embryonic stem cells, aiming to understand basic mechanisms of differentiation and to advance towards cell therapy of central nervous system diseases.