ACETYLCHOLINE TRANSITIONS OF THE ACETYLCHOLINE RECEPTOR
Stuart J. Edelstein and Jean-Pierre Changeux
Advances in Protein Chemistry 51: 121-184
CONTENTS:
I. Introduction
A. The acetylcholine receptor: similarities and differences with respect to other allosteric proteins
B. Consequences of pseudo-symmetric oligomeric structure
C. Role of mutational studies
II. Mechanistic models
A. The allosteric-type model
B. Linear free energy relations
C. Alternative models
III. Recovery from desensitization
IV. Kinetic basis of dose-response curves
A. Dependence on desensitization rate
B. Desensitization by low-concentration pre-pulses
V. Multiple phenotypes
A. Generalized allosteric network
B. The K phenotype
C. The L phenotype
D. The g phenotype
E. Limiting properties at extremes of L
VI. Deductions from single channel measurements
A. Kinetic consequences of mutant phenotypes
B. Single ionic events versus single ligand-binding events in relation to binding-site nonequivalence
VII. Allosteric effectors and coincidence detection
VIII. General Considerations
A. Evaluation of mechanistic models
B. Implications for synaptic plasticity
C. Diseases and nicotine dependency
References