About the PARKLAT project

Asymmetry of motor symptoms is common in Parkinson's disease, with more than 80% of patients experiencing either predominantly right-sided motor symptoms (RPD) or predominantly  left-sided motor symptoms (LPD), reflecting a contralateral hemispheric loss of dopamine in the basal ganglia. This asymmetric process seems to go beyond motor manifestations, differentially affecting non-motor symptoms in patients. Recent studies have indeed evidenced different cognitive and neuropsychiatric phenotypes when comparing patients based on motor symptom asymmetry and physiological markers. The aim of the PARKLAT project is to better understand how motor symptom asymmetry impacts the neuropsychological profile of patients with Parkinson's disease in the early stages of the disease, as well as following subthalamic nucleus deep brain stimulation.

Collaborators

Kévin Ahrweiller
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Neurology Department, Pontchaillou Hospital, Rennes University Hospital, Rennes, France

Dominique Drapier
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Adult Psychiatry Department, Guillaume Régnier Hospital, Rennes, France

Sophie Drapier
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Neurology Department, Pontchaillou Hospital, Rennes University Hospital, Rennes, France

Didier Grandjean
Neuroscience of Emotion and Affective Dynamics Laboratory (NEAD), Department of Psychology and Swiss Center for Affective Sciences, University of Geneva, Switzerland

Claire Haegelen
Neurosurgery Department, Pontchaillou Hospital, Rennes University Hospital, Rennes, France
MediCIS, INSERM-University of Rennes 1, Rennes, France

Jean-François Houvenaghel
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Neurology Department, Pontchaillou Hospital, Rennes University Hospital, France

Florence Le Jeune
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Nuclear Medicine Department, Eugène Marquis Center, Rennes, France

Paul Sauleau
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Physiology Department, Pontchaillou Hospital, Rennes University Hospital, Rennes, France

Marc Vérin
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Neurology Department, Pontchaillou Hospital, Rennes University Hospital, Rennes, France

Publications overview

• Voruz, P., Le Jeune, F., Haegelen, C., N’Diaye, K., Houvenaghel, JF., Sauleau, P., Drapier, S., Drapier, D. Grandjean, D., Vérin, M., & Péron, J. (2020). Motor symptom asymmetry in Parkinson’s disease predicts emotional outcome following STN DBS: An 18FDG-PET study. Neuropsychologia, 144, 107494.
• Benis, D., Haegelen, C. Voruz, P., Pierce, J., Milesi, V., Houvenaghel, JF., Vérin, M., Sauleau, P., Grandjean, D., & Péron, J. (2020). Subthalamic nucleus oscillations during vocal emotion processing are dependent of the motor asymmetry of Parkinson’s disease. Neuroimage, 222, 117215.
• Voruz, P., Pierce, J., Ahrweiller, K., Haegelen, C., Sauleau, P., Drapier, S., Drapier, D. Vérin, M., Péron, J. (2022). Motor symptom asymmetry predicts non-motor outcome and quality of life following STN DBS in Parkinson’s disease. Scientific Reports. doi: https://doi.org/10.1038/s41598-022-07026-5.
• Voruz, P., Constantin, I. M., & Péron, J. A. (2022). Biomarkers and non-motor symptoms as a function of motor symptom asymmetry in early Parkinson's disease. Neuropsychologia, 177, 108419.
• Constantin, IM, Voruz, P. and Péron, JA (2023). Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease. Biology of sex differences, 14 (1), 1-11 .