2022 FEBRUARY
Hepatic clearance
Drug Metab Dispos. 2022;50:187-190. In defense of current concepts and applications of clearance in drug development and therapeutics. Rowland M, Roberts MS, Pang KS. PubMed
Clin Pharmacol Ther. 2022;In press. Prediction of hepatobiliary clearances and hepatic concentrations of transported drugs in humans using Rosuvastatin as a model drug. Storelli F, Li CY, Sachar M, Kumar V, Heyward S, Sáfár Z, Kis E, Unadkat JD. PubMed
Hepatology. 2022;In press. Pastor CM. Letter to the editor: "On the mechanisms of biliary flux". PubMed
Original publication
Pharmacokinetic modelling
Toxicol Appl Pharmacol. 2022;In press. Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver. Hirasawa K, Abe J, Nagahori H, Kitamoto S. PubMed
Cholestatic livers
J Appl Toxicol. 2022;In press. Farnesoid X receptor contributes to oleanolic acid-induced cholestatic liver injury in mice. Feng H, Hu Y, Zhou S, Lu Y. PubMed
Liver-on-a-chip and cellular models
Lab Chip. 2022;In press. Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies. Docci L, Milani N, Ramp T, Romeo AA, Godoy P, Franyuti DO, Krähenbühl S, Gertz M, Galetin A, Parrott N, Fowler S. PubMed
J Toxicol Sci. 2022;47:39-50. HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane. Takezawa T, Uzu M. PubMed
Biol Pharm Bull. 2022;45:150-153. Directional drug transport through membrane-supported monolayers of human liver-derived cell lines. Mizoi K, Kobayashi M, Mashimo A, Matsumoto E, Masuda N, Itoh M, Ueno T, Tachiki H, Ishida S, Ogihara T. PubMed
Liver toxicity
Toxicol Appl Pharmacol. 2022;In press. Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278. Gill MW, Murphy BJ, Cheng PPT, Sivaraman L, Davis M, Lehman-McKeeman L. PubMed
HBV infection and NTCP
Biomedicines. 2022;10:196. Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a drug target for HBV infection: From protein engineering to drug discovery. Zakrzewicz D, Geyer J. PubMed
Transporter uptake function
ACS Omega. 2021;6:35844-35851. Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 are involved in the hepatic uptake of Phenolsulfonphthalein. Wang Z, Li Y, Peng T, Su Y, Luo X, Han W, Zhang H, Ruan J, Gui C. PubMed
Toxicol Appl Pharmacol. 2022;435:115848. Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1. Chen J, Xue Y, Shuai X, Ni C, Fang Z, Ye L, Hong M. PubMed
Drug Metab Dispos. 2021;IN press. Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells. Lim JJ, Suh Y, Faustman EM, Cui JY. PubMed