2023 APRIL
Transporters and pharmacogenetics
Clin Pharmacol Ther. 2023;113:782-793. PharmVar GeneFocus: SLCO1B1. Ramsey LB, Gong L, Lee SB, Wagner JB, Zhou X, Sangkuhl K, Adams SM, Straka RJ, Empey PE, Boone EC, Klein TE, Niemi M, Gaedigk A. PubMed
Expert Opin Drug Metab Toxicol. 2023;In press. Genetic variation in organic cation transporters and considerations in drug development. Varma MVS. PubMed
Experimental models
Clin Pharmacol Ther. 2023;In press. 3D spheroid primary human hepatocytes for prediction of cytochrome P450 and drug transporter induction. Järvinen E, Hammer HS, Pötz O, Ingelman-Sundberg M, Stage TB. PubMed
Clin Pharmacol Ther. 2023;In press. Novel explanted human liver model to assess hepatic extraction, biliary excretion, and transporter function. Stevens LJ, Dubbeld J, Doppenberg JB, van Hoek B, Menke AL, Donkers JM, Alsharaa A, de Vries A, Vaes WHJ, Knibbe CAJ, van de Steeg E, Alwayn IPJ. PubMed
Nat Rev Gastroenterol Hepatol. 2023;20:269 Human hepatocyte organoids model in early NAFLD. Hindson J. PubMed
Transporters and PBPK in liver disease
Clin Pharmacol Ther. 2023;In press. Dose adjustment in patients with liver cirrhosis - comparison of two different modeling approaches. Ozbey AC, Bachmann F, Duthaler U, Annaert P, Fowler S, Umehara K, Parrott N, Krähenbühl S. PubMed
Clin Pharmacol Ther. 2023;In press. Effect of chronic hepatitis C on the activity of the membrane transporters P-gp and OATP1B1/BCRP on patients with different stages of hepatic fibrosis. Pippa LF, Vieira CP, Caris JA, Rocha A, Marques MP, Garcia CP, Rezende REF, Lanchote VL. PubMed
Acta Pharm Sin B. 2023;13:1-28. Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients. Marie S, Frost KL, Hau RK, Martinez-Guerrero L, Izu JM, Myers CM, Wright SH, Cherrington NJ. PubMed
Hepatic clearance
Drug Metab Dispos. 2023;51:618-628. Exploring the pharmacokinetic mysteries of the liver: Application of series compartment models of hepatic elimination. Li X, Jusko WJ. PubMed
AAPS J. 2023;25:40. In vitro-in vivo extrapolation and scaling factors for clearance of human and preclinical species with liver microsomes and hepatocytes. Tess D, Chang GC, Keefer C, Carlo A, Jones R, Di L. PubMed
Pharm Res. 2023;40:937-949. Simplifying the Extended Clearance Concept Classification System (EC3S) to guide clearance prediction in drug discovery. Patel M, Riede J, Bednarczyk D, Poller B, Deshmukh SV. PubMed
Transporters and cryopreservation
Toxicol in vitro. 2023; In press. Drug transporter expression and activity in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice with humanized livers.
Regulation of OATP1B3
Pharmaceutics. 2023;15:738. Transcriptional regulation of liver-type OATP1B3 (Lt-OATP1B3) and cancer-type OATP1B3 (Ct-OATP1B3) studied in hepatocyte-derived and colon cancer-derived cell lines. Haberkorn B, Löwen D, Meier L, Fromm MF, König J. PubMed
Drug-induced cholestasis
Int J Mol Sci. 2023;24:5823. Molecular and clinical links between drug-induced cholestasis and familial intrahepatic cholestasis. Vitale G, Mattiaccio A, Conti A, Berardi S, Vero V, Turco L, Seri M, Morelli MC. PubMed