2023 AUGUST
Transporter inhibition
Drug Metab Dispos. 2023;51:950-961. The role of Coproporphyrins as endogenous biomarkers for Organic Anion Transporting Polypeptide 1B inhibition-progress from 2016 to 2023. Lai Y. PubMed
Drug Metab Dispos. 2023;51:982-994. The inhibitor preincubation effect is universal to SLC transporter assays and is only partially eliminated in the presence of extracellular protein. Tátrai P, Temesszentandrási-Ambrus C, Varga T, Gáborik Z. PubMed
Clin Pharmacol Ther. 2023;In press. A metabolomic analysis of sensitivity and specificity of 23 previously proposed biomarkers for renal transporter-mediated Drug-Drug Interactions. Gessner A, Müller F, Wenisch P, Heinrich MR, König J, Stopfer P, Fromm MF. PubMed
Eur J Drug Metab Pharmacokinet. 2023;48:397-410. Pharmacokinetics and Drug-Drug Interaction of Ocedurenone (KBP-5074) in vitro and in vivo. Wang P, Liu J, Tan X, Yang F, McCabe J, Zhang J. PubMed
Transporters and NASH
Drug Metab Dispos. 2023;51:970-981. Representative rodent models for renal transporter alterations in human Nonalcoholic Steatohepatitis. Frost KL, Jilek JL, Toth EL, Goedken MJ, Wright SH, Cherrington NJ. PubMed
Toxicol Sci. 2023;In press. Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis. Lastuvkova H, Nova Z, Hroch M, Alaei Faradonbeh F, Schreiberova J, Mokry J, Faistova H, Stefela A, Dusek J, Kucera O, Hyspler R, Dohnalkova E, Bayer RL, Hirsova P, Pavek P, Micuda S. PubMed
Hepatic clearance models
Drug Metab Dispos. 2023;51:1046-1052. Assumptions underlying hepatic clearance models: Recognizing the influence of saturable protein binding on driving force concentration and discrimination between models of hepatic clearance. Julia A Schulz Pauly, Jin Wang , Colin J Phipps, John Cory Kalvass. PubMed
Drug Metab Dispos. 2023;In press. Exploring the boundaries for in vitro-in vivo extrapolation: Use of isolated hepatocytes in co-culture and impact of albumin binding properties in the prediction of clearance of various drug types. Francis L, Ogungbenro K, De Bruyn T, Houston JB, Hallifax D. PubMed
Drug Metab Dispos. 2023;In press. Interpretation of protein-mediated uptake of statins by hepatocytes is confounded by the residual statin-protein complex. Yin M, Ishida K, Liang X, Lai Y, Unadkat JD. PubMed
Bile flow formation
Pharmacol Rev. 2023;In press. Hepatic bile formation: Developing a new paradigm. Javitt NB. PubMed
OATP1B1 function
Drug Metab Dispos. 2023;In press. Interaction of human OATP1B1 with PDZK1 is required for its trafficking to the hepatocyte plasma membrane. Wang P, Murray JW, Wolkoff AW. PubMed
DMD special Section on mechanism-based predictive methods in drug discovery and development
Drug Metab Dispos. 2023;51:1067-1076. A 20-year research overview: Quantitative prediction of hepatic clearance Using the in vitro-in vivo extrapolation approach based on Physiologically Based Pharmacokinetic modeling and Extended Clearance concept. Sugiyama Y, Aoki Y. PubMed
Drug Metab Dispos. 2023;51:1077-1088. Preincubation time-dependent, long-lasting inhibition of drug transporters and impact on the prediction of Drug-Drug Interactions. Nozaki Y, Izumi S. PubMed
Drug Metab Dispos. 2023;51:1089-1104. Evaluation of the selectivity of several Organic Anion Transporting Polypeptide 1B biomarkers using relative activity factor method. Chan GH, Houle R, Zhang J, Katwaru R, Li Y, Chu X. PubMed
Drug Metab Dispos. 2023;51:1105-1113. Progress in the quantitative assessment of transporter-mediated Drug-Drug Interactions Using endogenous substrates in clinical studies. Mochizuki T, Kusuhara H. PubMed
Drug Metab Dispos. 2023;51:1114-1126. Quantitative consideration of clinical increases in serum creatinine caused by renal transporter inhibition. Nakada T, Kudo T, Ito K. PubMed