2023 JUNE
Pharmacokinetic modeling of imaging agents
Pharm Res. 2023;In press. Application of pharmacokinetic modeling to characterize hepatobiliary disposition of imaging agents and alterations due to liver injury in isolated perfused rat livers. Jeong A, Pastor CM, Brouwer KLR. PubMed
Drug-drug interactions
Clin Pharmacol Ther. 2023;In press. The effect of Trimethoprim on Thiamine absorption: A transporter-mediated drug-nutrient interaction. Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM. PubMed
Eur J Pharm Sci. 2023;186:106459. In vitro validation of an in vivo phenotyping drug cocktail for major drug transporters in humans. Hsin CH, Kuehne A, Gu Y, Jedlitschky G, Hagos Y, Gründemann D, Fuhr U. PubMed
Drug Metab Dispos. 2023;51:844-850. Characterization of elimination pathways and the feasibility of endogenous metabolites as biomarkers of Organic Anion Transporter 1/3 Inhibition in Cynomolgus Monkeys. Liu R, Hao J, Zhao X, Lai Y. PubMed
Eur J Drug Metab Pharmacokinet. 2023;In press. Pharmacokinetics and drug-drug interaction of Ocedurenone (KBP-5074) in vitro and in vivo. Wang P, Liu J, Tan X, Yang F, McCabe J, Zhang J. PubMed
SLCO1B1 polymorphisms and Rosuvastatin efficacy
Eur Rev Med Pharmacol Sci. 2023;27:4708-4717. The lipid-lowering efficacy of rosuvastatin is associated with variations in SLCO1B1: a 12-month prospective cohort study. Zakria M, Hussain A, Ahmad N, Ahmed N, Rauf MA, Siraj S. PubMed
Prediction of plasma clearance
Mol Pharm. 2023;20:3438-3459. Drug design and success of prospective mouse in vitro-in vivo extrapolation (IVIVE) for predictions of plasma clearance (CLp) from hepatocyte intrinsic clearance (CLint). Manevski N, Umehara K, Parrott N. PubMed
J Pharmacol Exp Ther. 2023;In press. Quantitative prediction of OATP-mediated disposition and biliary clearance using human liver chimeric mice. Miyake T, Tsutsui H, Hirabayashi M, Tachibana T. PubMed
Bile canalicular function
Am J Physiol Gastrointest Liver Physiol. 2023;325:G14-G22. A modular analysis of bile canalicular function and its implications for cholestasis. Gupta K. PubMed
J Toxicol Sci. 2023;48:251-261. Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pharmaceutical and food-related compounds. Kitaguchi T, Horiuchi S, Kuroda Y, Ohno K, Kobayashi K, Tanaka M, Ishida S. PubMed
OATP and conjugated bile acids
Cell Mol Gastroenterol Hepatol. 2023;16:223-242. Organic Anion Transporting Polypeptide (OATP) 1B3 is a significant transporter for hepatic uptake of conjugated bile acids in humans.
Mol Pharm. 2023;20:3020-3032.Characterization of bile acid sulfate conjugates as substrates of human Organic Anion Transporting Polypeptides. Orozco CC, Neuvonen M, Bi YA, Cerny MA, Mathialagan S, Tylaska L, Rago B, Costales C, King-Ahmad A, Niemi M, Rodrigues AD. PubMed
Hepatic transporters of biomarkers
Drug Metab Dispos. 2023;In press. Evaluation of the selectivity of several OATP1B biomarkers using relative activity factor method. Chan GH, Houle R, Zhang J, Katwaru R, Li Y, Chu X. PubMed
Aquaporin-8 and steatosis
iScience. 2023;26:106561. Aquaporin-8 ameliorates hepatic steatosis through farnesoid X receptor in obese mice. Xiang M, Qian X, Han L, Wang H, Wang J, Liu W, Gu Y, Yao S, Yang J, Zhang Y, Peng Y, Zhang Z. PubMed
NTCP and hepatitis
Biol Chem. 2023;404:673-690. Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy. Zakrzewicz D, Geyer J. PubMed