2023 OCTOBER
Transporter inhibition
Clin Pharmacol Ther. 2023;In press. Development of 4-Pyridoxic acid PBPK model to support biomarker-informed evaluation of OAT1/3 inhibition and effect of chronic kidney disease. Tan SPF, Willemin ME, Snoeys J, Shen H, Rostami-Hodjegan A, Scotcher D, Galetin A. PubMed
Clin Pharmacol Ther. 2023;In press. TICBase: Integrated resource for data on drug and environmental chemical interactions with mammalian drug transporters. Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT. PubMed
Clin Pharmacol Ther. 2023;In press. Utilization of OATP1B biomarker Coproporphyrin-I to guide Drug-Drug Interaction risk assessment: Evaluation by the pharmaceutical industry.
Kikuchi R, Chothe PP, Chu X, Huth F, Ishida K, Ishiguro N, Jiang R, Shen H, Stahl SH, Varma MVS, Willemin ME, Morse BL. PubMed
Clin Pharmacol Ther. 2023;In press. Ticagrelor increases exposure to the Breast Cancer Resistance Protein substrate rosuvastatin. Lehtisalo M, Tarkiainen EK, Neuvonen M, Holmberg M, Kiiski JI, Lapatto-Reiniluoto O, Filppula AM, Kurkela M, Backman JT, Niemi M. PubMed
Drug Metab Dispos. 2023;51:1483-1489. Goldenseal-mediated inhibition of intestinal uptake transporters decreases Metformin systemic exposure in mice. Oyanna VO, Garcia-Torres KY, Bechtold BJ, Lynch KD, Call MR, Horváth M, Manwill PK, Graf TN, Cech NB, Oberlies NH, Paine MF, Clarke JD. PubMed
Transporter structure
Nat Commun. 2023 Sep 18;14:5774. Structure of human drug transporters OATP1B1 and OATP1B3. Ciută AD, Nosol K, Kowal J, Mukherjee S, Ramírez AS, Stieger B, Kossiakoff AA, Locher KP. PubMed
Annu Rev Biophys. 2023;52:275-300. Structure and mechanism of human ABC transporters. Alam A, Locher KP. PubMed
Drug Metab Dispos. 2023;51:904-922. How Cryo-EM has expanded our understanding of membrane transporters. Baril SA, Gose T, Schuetz JD. PubMed
Nat Commun. 2023;14:5035. The net electrostatic potential and hydration of ABCG2 affect substrate transport. Gose T, Aitken HM, Wang Y, Lynch J, Rampersaud E, Fukuda Y, Wills M, Baril SA, Ford RC, Shelat A, Mara MLO, Schuetz JD. PubMed
Pharmaceutics. 2023;15:2279. The double-leucine motifs affect internalization, stability, and function of Organic Anion Transporting Polypeptide 1B1. Wang X, Chen J, Huang J, Hong M. PubMed
PBPK models
Clin Pharmacol Ther. 2023;In press. Incorporation and performance verification of hepatic portal blood flow shunting in minimal and full PBPK models of liver cirrhosis. Small BG, Hatley O, Jamei M, Gardner I, Johnson TN. PubMed
Drug Metab Dispos. 2023;51:1403-1418. Utility of minimal Physiologically Based Pharmacokinetic Models for assessing fractional distribution, oral absorption, and series-compartment models of hepatic clearance. Li X, Jusko WJ. PubMed
Pharm Res. 2023;In press. Mechanistic static model based prediction of transporter substrate Drug-Drug Interactions utilizing Atorvastatin and Rifampicin. Mitra P, Kasliwala R, Iboki L, Madari S, Williams Z, Takahashi R, Taub ME. PubMed
Drug metabolising enzymes
Clin Pharmacol Ther. 2023;In press. Comparative intra-subject analysis of gene expression and protein abundance of major and minor drug metabolising enzymes in healthy human jejunum and liver. Wenzel C, Lapczuk-Romanska J, Malinowski D, Ostrowski M, Drozdzik M, Oswald S. PubMed
Hepatic clearance
Drug Metab Dispos. 2023;51:1451-1454. Kirchhoff's laws and hepatic clearance, well-stirred model. Is there common ground? Rowland M, Weiss M, Pang KS. PubMed
Liver injury
Arch Toxicol. 2023;97:3259-3271. OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects. Haas M, Ackermann G, Küpper JH, Glatt H, Schrenk D, Fahrer J. PubMed.
Experimental models
In Vitro Cell Dev Biol Anim. 2023;59:606-614. Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time. Sakai Y, Matsumura M, Iwao T, Matsunaga T. PubMed
PLoS One. 2023;18:e0291822. Development of multi-drug resistance to anticancer drugs in HepG2 cells due to MRP2 upregulation on exposure to menthol. Nagai K, Tamura M, Murayama R, Fukuno S, Ito T, Konishi H. PubMed
Sci Rep. 2023;13:15837. Micro-patterned primary hepatocyte co-culture (HEPATOPAC) for fatty liver disease modeling and drug screening. Cottier KE, Bhalerao D, Lewis C, Gaffney J, Heyward SA. PubMed
Biochemistry. 2023;88:1267-1273. Generation of a cell line selectively producing functionally active OATP1B1 transporter. Kotliarova MS, Shchulkin AV, Erokhina PD, Mylnikov PY, Yakusheva EN, Nadolinskaia NI, Zamakhaev MV, Goncharenko AV. PubMed