2024 APRIL
Transporter information in prestigious journals
Nat Rev Gastroenterol Hepatol. 2024;in press. New understanding of hepatobiliary MRI. Pastor CM, Vilgrain V. PubMed
Shared link
Nat Rev Drug Discov. 2024;23:255-280. Membrane transporters in drug development and as determinants of precision medicine. Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM. PubMed
Transporter functions and interactions
J Pharmacol Exp Ther. 2024;389:87-95. Humanization of SLCO2B1 in rats increases rCYP3A1 protein expression but not the metabolism of Erlotinib to OSI-420. Rysz M, Schäfer AM, Paloumpis N, Kinzi J, Brecht K, Seibert I, Schmidlin S, In-Albon K, Ricklin D, Meyer Zu Schwabedissen HE. PubMed
Drug Metab Dispos. 2024;52:312-321. Interaction and transport of Benzalkonium chlorides by the Organic Cation and Multidrug and Toxin Extrusion Transporters. Vieira LS, Seguin RP, Xu L, Wang J. PubMed
Clin Pharmacol Ther. 2024;In press. A clinical practice perspective on the evaluation of OATP1B1-associated drug interactions. Stäuble CK, Lampert ML, Allemann SS, Meyer Zu Schwabedissen HE. PubMed
Environ Health Prev Med. 2024;29:21. Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice. Furukawa K, Okamoto-Matsuda K, Harada KH, Minata M, Hitomi T, Kobayashi H, Koizumi A. PubMed
Nat Commun. 2024;15:2476. Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sørensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP. PubMed
Nat Commun. 2024 Mar;15:1983. Structural basis for the modulation of MRP2 activity by phosphorylation and drugs. Mazza T, Roumeliotis TI, Garitta E, Drew D, Rashid ST, Indiveri C, Choudhary JS, Linton KJ, Beis K. PubMed
Experimental models
Drug Metab Dispos. 2024;52:296-304. Use of a double-transfected system to predict hOCT2/hMATE1-mediated renal drug-drug interactions.
Vieira LS, Wang J. PubMed
Biotechnol J. 2024;19:e2300587. The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function. Xing C, Kemas A, Mickols E, Klein K, Artursson P, Lauschke VM. PubMed
Pharmacol Rep. 2024;In press. Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran. Kowal-Chwast A, Gabor-Worwa E, Gaud N, Gogola D, Piątek A, Zarębski A, Littlewood P, Smoluch M, Brzózka K, Kuś K. PubMed
Artorvastatin pharmacokinetics
Clin Pharmacol Ther. 2024;In press. Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP. Mykkänen AJH, Tarkiainen EK, Taskinen S, Neuvonen M, Paile-Hyvärinen M, Lilius TO, Tapaninen T, Klein K, Schwab M, Backman JT, Tornio A, Niemi M. PubMed
Drug resistance in hepatocellular carcinoma
Hepatology. 2024 Apr 1;79:926-940. Mechanisms of drug resistance in HCC. Ladd AD, Duarte S, Sahin I, Zarrinpar A. PubMed.
Hepatic drug clearance
Eur J Pharm Sci. 2024;In press. Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance? Benet LZ, Sodhi JK. PubMed
Reviews
Biochem Pharmacol. 2024;In press. Impact of liver diseases and pharmacological interactions on the transportome involved in hepatic drug disposition. Marin JJG, Cives-Losada C, Macias RIR, Romero MR, Marijuan RP, Hortelano-Hernandez N, Delgado-Calvo K, Villar C, Gonzalez-Santiago JM, Monte MJ, Asensio M. PubMed
Drug-induced liver injury
Drug Metab Dispos. 2024;In press. CYP7A1 gene induction via SHP-dependent or independent mechanisms can increase the risk of drug-induced liver injury independently or in synergy with BSEP inhibition. Niu C, Xie X, Liu R, Liang X, Hu Y, Lai Y. PubMed