2024 FEBRUARY
Transporters and hepatobiliary imaging
Korean J Radiol. 2024;25:24-32. Evaluation and prediction of post-hepatectomy liver failure using imaging techniques: Value of Gadoxetic acid-enhanced Magnetic Resonance Imaging. Sofue K, Shimada R, Ueshima E, Komatsu S, Yamaguchi T, Yabe S, Ueno Y, Hori M, Murakami T. PubMed
Drug Metab Dispos. 2024;52:118-125. Association between Gadoxetic acid-enhanced Magnetic Resonance Imaging, organic anion transporters, and Farnesoid X receptor in benign focal liver lesions. van Rosmalen BV, Visentin M, Furumaya A, van Delden OM, Kazemier G, van Gulik TM, Verheij J, Stieger B. PubMed
Inhibition of transporter function
Drug Metab Dispos. 2024;52:236-241. Assessing pleiotropic effects of a mixed-mode perpetrator drug, Rifampicin, by multiple endogenous biomarkers in dogs. Liu R, Ma B, Mok MM, Murray BP, Subramanian R, Lai Y. PubMed
Clin Pharmacol Ther. 2024;In press. Mechanistic determinants of Daprodustat drug-drug interactions and pharmacokinetics in hepatic dysfunction and chronic kidney disease: Significance of OATP1B-CYP2C8 interplay. Bi YA, Jordan S, King-Ahmad A, West MA, Varma MVS. PubMed
Drug Metab Dispos. 2024;In press. Low molecular weight acids and OATP1B mediated hepatic clearance: In vitro and in vivo evaluation using novel hypoxia-inducible factor prolyl hydroxylase inhibitors (Dustats). Bi YA, Jordan S, King-Ahmad A, West MA, Yamaguchi E, Ryu S, Mathialagan S, Tess DA, Varma MVS. PubMed
Toxicology. 2024;503:153757. Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice. Chen M, Yi Y, Chen B, Zhang H, Dong M, Yuan L, Zhou H, Jiang H, Ma Z. PubMed
NTCP and cholestasis
Front Pharmacol. 2024;15:1341651. Chishao (Paeoniae Radix Rubra) alleviates intra-hepatic cholestasis by modulating NTCP in rats. Sun X, Fang J, Fang N. PubMed
Experimental models
Toxicol Sci. 2024;In press. Development of a human liver microphysiological co-culture system for higher throughput chemical safety assessment. Ip BC, Madnick SJ, Zheng S, van Tongeren TCA, Hall SJ, Li H, Martin S, Spriggs S, Carmichael P, Chen W, Ames D, Breitweiser LA, Pence HE, Bowling AJ, Johnson KJ, Cubberley R, Morgan JR, Boekelheide K. PubMed
Biol Pharm Bull. 2024;47:427-433. Novel screening system for biliary excretion of drugs using human cholangiocyte organoid monolayers with directional drug transport. Mizoi K, Okada R, Mashimo A, Masuda N, Itoh M, Ishida S, Yamazaki D, Ogihara T. PubMed
Front Bioeng Biotechnol. 2023;11:1303053. Microscale tissue engineering of liver lobule models: advancements and applications. Wang Q, Liu J, Yin W, Wang A, Zheng J, Wang Y, Dong J. PubMed
Biomicrofluidics. 2023;17:064103. A method to generate perfusable physiologic-like vascular channels within a liver-on-chip model. Ferrari E, Monti E, Cerutti C, Visone R, Occhetta P, Griffith LG, Rasponi M. PubMed
Transporter structure and function
Cell Biol Int. 2024;In press. The noncanonical nucleotide binding site 1 of the bile salt export pump is optimized for proper function of the transporter. Sohail I, Hassan MU, Schmid D, Chiba P. PubMed
Nat Commun. 2024;15:1061. Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Mao YX, Chen ZP, Wang L, Wang J, Zhou CZ, Hou WT, Chen Y. PubMed
J Med Chem. 2024;67:1406-1420. Discovery of TP0628103: A highly potent and selective MMP-7 inhibitor with reduced OATP-mediated clearance designed by shifting isoelectric points. Oka Y, Abe-Sato K, Tabuse H, Yasukawa Y, Yahara T, Nishimoto T, Kamitani M, Fukunaga T, Ochiai N, Kumasaka-Abe T, Hitaka K, Gunji E, Ohara H, Takeda T, Kojima N, Asami T. PubMed
Chem Res Toxicol. 2024;37:57-71. Natural product Baohuoside impairs the stability and membrane location of MRP2 reciprocally regulated by SUMOylation and Ubiquitination in hepatocytes. Zhao Z, Du JF, Wang QL, Qiu FN, Li P, Jiang Y, Li HJ. PubMed
J Cell Mol Med. 2024, 3:e18110. Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCalpha-associated signalling under cholesterol stimulation. Pang L, Cui M, Wu S, Kong J. PubMed
Transporters and NAFLD, hepatitis, and cirrhosis
Biochim Biophys Acta Mol Basis Dis. 2024;1870:167037. Impact of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) on the expression and function of hepatobiliary transporters: A comprehensive mechanistic review. Laddha AP, Dzielak L, Lewis C, Xue R, Manautou JE. PubMed
Hepatol Commun. 2024;8:e0377. Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Murphy WA, Diehl AM, Loop MS, Fu D, Guy CD, Abdelmalek MF, Karachaliou GS, Sjöstedt N, Neuhoff S, Honkakoski P, Brouwer KLR. PubMed
Front Pharmacol. 2023;14:1279357. Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice. Fendt R, Ghallab A, Myllys M, Hofmann U, Hassan R, Hobloss Z, González D, Brackhagen L, Marchan R, Edlund K, Seddek AL, Abdelmageed N, Blank LM, Schlender JF, Holland CH, Hengstler JG, Kuepfer L. PubMed
Biochem Pharmacol. 2024;219:115956. Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics. Zhang Z, Zhang Q, Zhang Y, Lou Y, Ge L, Zhang W, Zhang W, Song F, Huang P. PubMed
Hepatobiliary toxicity
Toxicol Pathol. 2024;In press. Risk assessment for hepatobiliary toxicity liabilities in drug development. Miller RT. PubMed
Drug Chem Toxicol. 2024;In press. Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway. Shang S, Li W, Zhou F, Zhao Y, Yu M, Tong L, Xin H, Yu A. PubMed