2022 APRIL
ICT publication
Clin Pharmacol Ther. 2022;In press. Regulation of drug transport proteins - From mechanisms to clinical impact; A white paper on behalf of the ITC. Brouwer KLR, Evers R, Hayden E, Hu S, Li CY, Meyer Zu Schwabedissen HE, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl J, Stahl SH, Yue W. PubMed
Clin Pharmacol Ther. 2022 ;In press. New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium. Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X. PubMed
Hepatic clearance
Eur J Pharm Sci. 2022;172:106134. A myth of the well-stirred model: Is the well-stirred model good for high clearance drugs? Dong J, Park MS. PubMed
Pharm Res. 2022;in press. In vitro - in vivo extrapolation of hepatic clearance in preclinical species. Tess DA, Ryu S, Di L. PubMed
Transporters and species
Drug Metab Pharmacokinet. 2022;43:100437. Systematic identification and characterization of cynomolgus macaque solute carrier transporters. Uno Y, Yamazaki H. PubMed
Drug Metab Dispos. 2022;50:299-319. Cynomolgus monkey as an emerging animal model to study drug transporters: In vitro, in vivo, in vitro-to-in vivo translation. Shen H, Yang Z, Rodrigues AD. PubMed
Pharmacogenetics of transporters
Clin Pharmacol Ther. 2022 ;In press. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-associated musculoskeletal symptoms. Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. PubMed
Clin Pharmacol Ther. 2022 ;In press. SLCO1B1*5 Allele is associated with Atorvastatin discontinuation and adverse muscle symptoms in the context of routine care. Voora D, Baye J, McDermaid A, Narayana Gowda S, Wilke RA, Nicole Myrmoe A, Hajek C, Larson EA. PubMed
Transporter-dependent DDI
Clin Pharmacol Ther. 2022 ;In press. Effect of cyclosporin A and impact of dose staggering on OATP1B1/1B3 endogenous substrates and drug probes for assessing clinical drug interactions. Mochizuki T, Zamek-Gliszczynski MJ, Yoshida K, Mao J, Taskar K, Hirabayashi H, Chu X, Lai Y, Takashima T, Rockich K, Yamaura Y, Fujiwara K, Mizuno T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. PubMed
Clin Pharmacol Ther. 2022 ;In press. Evaluation of the effect of Abrocitinib on drug transporters by integrated use of probe drugs and endogenous biomarkers. Vourvahis M, Byon W, Chang C, Le V, Diehl A, Graham D, Tripathy S, Raha N, Luo L, Mathialagan S, Dowty M, Rodrigues AD, Malhotra B. PubMed
Pharm Res. 2022 ;In press. High throughput screening of a prescription drug library for inhibitors of Organic Cation Transporter 3, OCT3. Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM. PubMed
Clin Pharmacol Ther. 2022 ;In press. Blockade of organic anion transport in humans after treatment with the drug probenecid leads to major metabolic alterations in plasma and urine. Granados JC, Bhatnagar V, Nigam SK. PubMed
Proteomics of drug-metabolising enzymes and obesity
Clin Pharmacol Ther. 2022 ;In press. Drug disposition protein quantification in matched human jejunum and liver from donors with obesity. Wegler C, Wiśniewski JR, Robertsen I, Christensen H, Kristoffer Hertel J, Hjelmesaeth J, Jansson-Löfmark R, Åsberg A, Andersson TB, Artursson P. PubMed
Transporters of the kidney
Physiol Rev. 2022;102:993-1024. Regulation of solute carriers oct2 and OAT1/3 in the kidney: a phylogenetic, ontogenetic, and cell dynamic perspective. Pou Casellas C, Jansen K, Rookmaaker MB, Clevers H, Verhaar MC, Masereeuw R. PubMed
Transporter functions
Front Physiol. 2022;13:859294. Multidrug Resistance-Associated Protein 2 deficiency aggravates estrogen-induced impairment of bile acid metabolomics in rats. Alaei Faradonbeh F, Lastuvkova H, Cermanova J, Hroch M, Nova Z, Uher M, Hirsova P, Pavek P, Micuda S. PubMed
Drug Metab Dispos. 2021 ;In press. Emerging roles of the Human Solute Carrier 22 family. Yee SW, Giacomini KM. PubMed
Structural plasticity of NTPC
Int J Mol Sci. 2022;23:3211. Structural plasticity is a feature of rheostat positions in the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP). Ruggiero MJ, Malhotra S, Fenton AW, Swint-Kruse L, Karanicolas J, Hagenbuch B. PubMed
Protein-mediated uptake of OATP
Drug Metab Dispos. 2022 ;In press. Is the protein-mediated uptake of drugs by OATPs : A real phenomenon or an artifact? Yin M, Storelli F, Unadkat JD. PubMed
Bile acids and acetaminophen toxicity
J Hepatol. 2022 ;In press. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. Ghallab A, Hassan R, Hofmann U, Friebel A, Hobloss Z, Brackhagen L, Begher-Tibbe B, Myllys M, Reinders J, Overbeck N, Sezgin S, Zühlke S, Seddek AL, Murad W, Brecklinghaus T, Kappenberg F, Rahnenführer J, González D, Goldring C, Copple IM, Marchan R, Longerich T, Vucur M, Luedde T, Urban S, Canbay A, Schreiter T, Trauner M, Akakpo JY, Olyaee M, Curry SC, Sowa JP, Jaeschke H, Hoehme S, Hengstler JG. PubMed
Modeling in liver disease
Clin Pharmacol Ther. 2022 ;In press. Considerations for physiologically based modeling in liver disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH). Murphy WA, Adiwidjaja J, Sjöstedt N, Yang K, Beaudoin JJ, Spires J, Siler SQ, Neuhoff S, Brouwer KLR. PubMed
Transporters and endotoxemia
Pharmaceuticals. 2022;15:392. Pharmacokinetic Imaging using 99mTc-Mebrofenin to untangle the pattern of hepatocyte transporter disruptions induced by endotoxemia in rats. Marie S, Hernández-Lozano I, Le Vée M, Breuil L, Saba W, Goislard M, Goutal S, Truillet C, Langer O, Fardel O, Tournier N. PubMed