2023 Q4 Publications by GCIR members | October to December

A phase Ib/II randomized, open-label drug repurposing trial of glutamate signaling inhibitors in combination with chemoradiotherapy in patients with newly diagnosed glioblastoma: the GLUGLIO trial protocol.

Mastall M, Roth P, Bink A, Fischer Maranta A, Läubli H, Hottinger AF, Hundsberger T, Migliorini D, Ochsenbein A, Seystahl K, Imbach L, Hortobagyi T, Held L, Weller M, Wirsching HG.

BMC Cancer. 2024 Jan 15;24(1):82. doi: 10.1186/s12885-023-11797-z.

PMID: 38225589

GM-CSF in Allogenic Hematopoietic Stem Cell Transplantation: from Graft-versus-Host Disease to Graft-versus-Tumor effect.

Bernardi C, Charvet C, Zeiser R, Simonetta F.

Transplant Cell Ther. 2024 Jan 13:S2666-6367(24)00141-6. doi: 10.1016/j.jtct.2024.01.060. 

PMID: 38224950 Review.

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial.

Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, Kothari S, Guyonnet L, Guerin CL, Waterfall JJ, Mohan S, Hwang WT, Tang OY, Logun M, Bhattacharyya M, Markowitz K, Delman D, Marshall A, Wherry EJ, Amigorena S, Beatty GL, Brogdon JL, Hexner E, Migliorini D, Alanio C, O'Rourke DM.

Nat Cancer. 2024 Jan 12. doi: 10.1038/s43018-023-00709-6. 

PMID: 38216766

Id3 keeps the PD-1 checkpoint in check in GVHD.

Bernardi C, Simonetta F.

Blood. 2024 Jan 11;143(2):103-104. doi: 10.1182/blood.2023022712.

PMID: 38206642  

Time-of-flight and black-blood MRI to study intracranial arteries in rats.

Cayron AF, Bejuy O, Vargas MI, Colin DJ, Aoki T, Lövblad KO, Bijlenga P, Kwak BR, Allémann E, Morel S.

Eur Radiol Exp. 2024 Jan 9;8(1):3. doi: 10.1186/s41747-023-00407-z.

PMID: 38191711  

Sustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins.

Dos Santos Pacheco N, Tell I Puig A, Guérin A, Martinez M, Maco B, Tosetti N, Delgado-Betancourt E, Lunghi M, Striepen B, Chang YW, Soldati-Favre D.

Nat Commun. 2024 Jan 9;15(1):379. doi: 10.1038/s41467-023-44631-y.

PMID: 38191574  

Regulation of the transcription factor CdnL promotes adaptation to nutrient stress in Caulobacter.

Smith EL, Panis G, Woldemeskel SA, Viollier PH, Chien P, Goley ED.

bioRxiv. 2023 Dec 21:2023.12.20.572625. doi: 10.1101/2023.12.20.572625. 

PMID: 38187569

Predictors of treatment switching in the Big Multiple Sclerosis Data Network.

Spelman T, Magyari M, Butzkueven H, Van Der Walt A, Vukusic S, Trojano M, Iaffaldano P, Horáková D, Drahota J, Pellegrini F, Hyde R, Duquette P, Lechner-Scott J, Sajedi SA, Lalive P, Shaygannejad V, Ozakbas S, Eichau S, Alroughani R, Terzi M, Girard M, Kalincik T, Grand'Maison F, Skibina O, Khoury SJ, Yamout B, Sa MJ, Gerlach O, Blanco Y, Karabudak R, Oreja-Guevara C, Altintas A, Hughes S, McCombe P, Ampapa R, de Gans K, McGuigan C, Soysal A, Prevost J, John N, Inshasi J, Stawiarz L, Manouchehrinia A, Forsberg L, Sellebjerg F, Glaser A, Pontieri L, Joensen H, Rasmussen PV, Sejbaek T, Poulsen MB, Christensen JR, Kant M, Stilund M, Mathiesen H, Hillert J; Big MS Data Network: a collaboration of the Czech MS Registry, the Danish MS Registry, Italian MS Registry, Swedish MS Registry, MSBase Study Group, and OFSEP.

Front Neurol. 2023 Dec 22;14:1274194. doi: 10.3389/fneur.2023.1274194. eCollection 2023.

PMID: 38187157

Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum.

Lisauskaitė M, Nixon GL, Woodley CM, Berry NG, Coninckx A, Qie LC, Leung SC, Taramelli D, Basilico N, Parapini S, Ward SA, Vadas O, Soldati-Favre D, Hong WD, O'Neill PM.

RSC Chem Biol. 2023 Nov 13;5(1):19-29. doi: 10.1039/d3cb00109a. eCollection 2024 Jan 3.

PMID: 38179191

Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer.

Poinot H, Dupuychaffray E, Arnoux G, Alvarez M, Tachet J, Ezzar O, Moore J, Bejuy O, Olesti E, Visconti G, González-Ruiz V, Rudaz S, Tille JC, Voegel CD, Nowak-Sliwinska P, Bourquin C, Pommier A.

Oncoimmunology. 2023 Nov 30;13(1):2286820. doi: 10.1080/2162402X.2023.2286820. eCollection 2024.

PMID: 38170044

Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.

Cagol A, Benkert P, Melie-Garcia L, Schaedelin SA, Leber S, Tsagkas C, Barakovic M, Galbusera R, Lu PJ, Weigel M, Ruberte E, Radue EW, Yaldizli Ö, Oechtering J, Lorscheider J, D'Souza M, Fischer-Barnicol B, Müller S, Achtnichts L, Vehoff J, Disanto G, Findling O, Chan A, Salmen A, Pot C, Bridel C, Zecca C, Derfuss T, Lieb JM, Remonda L, Wagner F, Vargas MI, Du Pasquier RA, Lalive PH, Pravatà E, Weber J, Cattin PC, Absinta M, Gobbi C, Leppert D, Kappos L, Kuhle J, Granziera C.

Neurology. 2024 Jan 9;102(1):e207768. doi: 10.1212/WNL.0000000000207768. Epub 2023 Dec 13.

PMID: 38165377

Genetic knockout of NTRK2 by CRISPR/Cas9 decreases neurogenesis and favors glial progenitors during differentiation of neural progenitor stem cells.

Roussel-Gervais A, Sgroi S, Cambet Y, Lemeille S, Seredenina T, Krause KH, Jaquet V.

Front Cell Neurosci. 2023 Dec 14;17:1289966. doi: 10.3389/fncel.2023.1289966. eCollection 2023.

PMID: 38161998

Portosystemic shunting prevents hepatocellular carcinoma in non-alcoholic fatty liver disease mouse models.

Peloso A, Lacotte S, Gex Q, Slits F, Moeckli B, Oldani G, Tihy M, Hautefort A, Kwak B, Rubbia-Brandt L, Toso C.

PLoS One. 2023 Dec 29;18(12):e0296265. doi: 10.1371/journal.pone.0296265. eCollection 2023.

PMID: 38157359

[Oxytocin as a neuroprotective strategy in neonates: concept and preclinical evidence].

Baud O, Knoop M.

Gynecol Obstet Fertil Senol. 2023 Dec 23:S2468-7189(23)00257-X. doi: 10.1016/j.gofs.2023.12.005.

PMID: 38145743 French.

c-Met⁺ Cytotoxic T Lymphocytes Exhibit Enhanced Cytotoxicity in Mice and Humans In Vitro Tumor Models.

Benkhoucha M, Tran NL, Senoner I, Breville G, Fritah H, Migliorini D, Dutoit V, Lalive PH.

Biomedicines. 2023 Nov 23;11(12):3123. doi: 10.3390/biomedicines11123123.

PMID: 38137344

Strategies to decrease inequalities in cancer therapeutics, care and prevention.

Ringborg U, von Braun J, Celis J, Baumann M, Berns A, Eggermont A, Heard E, Heitor M, Chandy M, Chen CJ, Costa A, De Lorenzo F, De Robertis EM, Dubee FC, Ernberg I, Gabriel M, Helland Å, Henrique R, Jönsson B, Kallioniemi O, Korbel J, Krause M, Lowy DR, Michielin O, Nagy P, Oberst S, Paglia V, Parker MI, Ryan K, Sawyers CL, Schüz J, Silkaitis K, Solary E, Thomas D, Turkson P, Weiderpass E, Yang H.

Mol Oncol. 2023 Dec 22. doi: 10.1002/1878-0261.13575. 

PMID: 38135904

Swiss digital pathology recommendations: results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology.

Janowczyk A, Zlobec I, Walker C, Berezowska S, Huschauer V, Tinguely M, Kupferschmid J, Mallet T, Merkler D, Kreutzfeldt M, Gasic R, Rau TT, Mazzucchelli L, Eyberg I, Cathomas G, Mertz KD, Koelzer VH, Soldini D, Jochum W, Rössle M, Henkel M, Grobholz R; Swiss Digital Pathology Consortium.

Virchows Arch. 2023 Dec 19. doi: 10.1007/s00428-023-03712-5. Online ahead of print.

PMID: 38112792

A quantitative model for virus uncoating predicts influenza A infectivity.

Artcibasova A, Wang L, Anchisi S, Yamauchi Y, Schmolke M, Matthias P, Stelling J.

Cell Rep. 2023 Dec 26;42(12):113558. doi: 10.1016/j.celrep.2023.113558. Epub 2023 Dec 14.

PMID: 38103200

A potential role for chlamydial infection in rheumatoid arthritis development.

Lamacchia C, Aymon R, Hattel BC, Aeby S, Kebbi-Beghdadi C C, Gilbert B, Studer O, Norris JM, Nolers MV, Demoruelle MK, Feser ML, Moss L, Courvoisier DS, Lauper K, Deane KD, Greub G G, Finckh A.

Rheumatology (Oxford). 2023 Dec 13:kead682. doi: 10.1093/rheumatology/kead682. Online ahead of print.

PMID: 38092030

The autoinflammation-associated NLRC4^V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice.

Eeckhout E, Asaoka T, Van Gorp H, Demon D, Girard-Guyonvarc'h C, Andries V, Vereecke L, Gabay C, Lamkanfi M, van Loo G, Wullaert A.

Front Immunol. 2023 Nov 28;14:1272639. doi: 10.3389/fimmu.2023.1272639. eCollection 2023.

PMID: 38090573

Sex differences in adverse events from systemic treatments for psoriasis: A decade of insights from the Swiss Psoriasis Registry (SDNTT).

Verardi F, Maul LV, Borsky K, Steinmann S, Rosset N, Pons HO, Sorbe C, Yawalkar N, Micheroli R, Egeberg A, Thyssen JP, Heidemeyer K, Boehncke WH, Conrad C, Cozzio A, Pinter A, Kündig T, Navarini AA, Maul JT.

J Eur Acad Dermatol Venereol. 2023 Dec 12. doi: 10.1111/jdv.19730.

PMID: 38084852

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound and urinary tract infections.

Tan CAZ, Chong KKL, Yeong DYX, Ng CHM, Ismail MH, Yap ZH, Khetrapal V, Tay VSY, Drautz-Moses DI, Ali Y, Chen SL, Kline KA.

mBio. 2023 Dec 11:e0238423. doi: 10.1128/mbio.02384-23.  

PMID: 38078746

Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study.

Alberto C, Lambeng N, Deffert C, Breville G, Gayet-Ageron A, Lalive P, Calmy A, Coste A, Papadimitriou-Olivgeris M, Braun D, Lienhard R, Bosshard PP, Fontao L, Toutous Trellu L.

Sex Transm Infect. 2023 Dec 7:sextrans-2023-055913. doi: 10.1136/sextrans-2023-055913.

PMID: 38071543

Evaluation of discontinuation for adverse events of JAK inhibitors and bDMARDs in an international collaboration of rheumatoid arthritis registers (the 'JAK-pot' study).

Aymon R, Mongin D, Bergstra SA, Choquette D, Codreanu C, De Cock D, Dreyer L, Elkayam O, Huschek D, Hyrich KL, Iannone F, Inanc N, Kearsley-Fleet L, Koca SS, Kvien TK, Leeb BF, Lukina G, Nordström DC, Pavelka K, Pombo-Suarez M, Rodrigues A, Rotar Z, Strangfeld A, Verschueren P, Westermann R, Zavada J, Courvoisier DS, Finckh A, Lauper K.

Ann Rheum Dis. 2023 Dec 8:ard-2023-224670. doi: 10.1136/ard-2023-224670.

PMID: 38071508

The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation.

Carreras-Sureda A, Zhang X, Laubry L, Brunetti J, Koenig S, Wang X, Castelbou C, Hetz C, Liu Y, Frieden M, Demaurex N.

Cell Rep. 2023 Dec 26;42(12):113540. doi: 10.1016/j.celrep.2023.113540. Epub 2023 Dec 5.

PMID: 38060449

Adaptive β-lactam resistance from an inducible efflux pump that is post-translationally regulated by the DjlA co-chaperone.

Costafrolaz J, Panis G, Casu B, Ardissone S, Degeorges L, Pilhofer M, Viollier PH.

PLoS Biol. 2023 Dec 5;21(12):e3002040. doi: 10.1371/journal.pbio.3002040. eCollection 2023 Dec.

PMID: 38051727

Influenza A virus infection alters the resistance profile of gut microbiota to clinically relevant antibiotics.

Robas M, Presa J, Arranz-Herrero J, Yildiz S, Rius-Rocabert S, Llinares-Pinel F, Probanza A, Schmolke M, Jiménez PA, Nistal-Villan E.

Microbiol Spectr. 2024 Jan 11;12(1):e0363522. doi: 10.1128/spectrum.03635-22. Epub 2023 Dec 5.

PMID: 38051056

Oral glucocorticoid use in patients with rheumatoid arthritis initiating TNF-inhibitors, tocilizumab or abatacept: Results from the international TOCERRA and PANABA observational collaborative studies.

Lauper K, Mongin D, Bergstra SA, Choquette D, Codreanu C, Gottenberg JE, Kubo S, Hetland ML, Iannone F, Kristianslund EK, Kvien TK, Lukina G, Mariette X, Nordström DC, Pavelka K, Pombo-Suarez M, Rotar Z, Santos MJ, Tanaka Y, Turesson C, Courvoisier DS, Finckh A, Gabay C.

Joint Bone Spine. 2023 Nov 30;91(2):105671. doi: 10.1016/j.jbspin.2023.105671.

PMID: 38042363

iU-ExM: nanoscopy of organelles and tissues with iterative ultrastructure expansion microscopy.

Louvel V, Haase R, Mercey O, Laporte MH, Eloy T, Baudrier É, Fortun D, Soldati-Favre D, Hamel V, Guichard P.

Nat Commun. 2023 Nov 30;14(1):7893. doi: 10.1038/s41467-023-43582-8.

PMID: 38036510

The SYSCID map: a graphical and computational resource of molecular mechanisms across rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease.

Acencio ML, Ostaszewski M, Mazein A, Rosenstiel P, Aden K, Mishra N, Andersen V, Sidiropoulos P, Banos A, Filia A, Rahmouni S, Finckh A, Gu W, Schneider R, Satagopam V.

Front Immunol. 2023 Nov 1;14:1257321. doi: 10.3389/fimmu.2023.1257321. eCollection 2023.

PMID: 38022524

Adjuvant or neoadjuvant treatment with immune checkpoint inhibitors: re-assessing the risk-benefit ratio.

Delyon J, Michielin O.

Lancet Oncol. 2024 Jan;25(1):3-5. doi: 10.1016/S1470-2045(23)00575-2. Epub 2023 Nov 25.

PMID: 38012894  

Intercellular Communication in Airway Epithelial Cell Regeneration: Potential Roles of Connexins and Pannexins.

Badaoui M, Chanson M.

Int J Mol Sci. 2023 Nov 10;24(22):16160. doi: 10.3390/ijms242216160.

PMID: 38003349 Review.

MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration.

Winkler I, Engler JB, Vieira V, Bauer S, Liu YH, Di Liberto G, Grochowska KM, Wagner I, Bier J, Bal LC, Rothammer N, Meurs N, Egervari K, Schattling B, Salinas G, Kreutz MR, Huang YS, Pless O, Merkler D, Friese MA.

Sci Adv. 2023 Nov 24;9(47):eadi6855. doi: 10.1126/sciadv.adi6855. Epub 2023 Nov 24.

PMID: 38000031

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy.

Ghasemi A, Martinez-Usatorre A, Li L, Hicham M, Guichard A, Marcone R, Fournier N, Torchia B, Martinez Bedoya D, Davanture S, Fernández-Vaquero M, Fan C, Janzen J, Mohammadzadeh Y, Genolet R, Mansouri N, Wenes M, Migliorini D, Heikenwalder M, De Palma M.

Nat Cancer. 2023 Nov 23. doi: 10.1038/s43018-023-00668-y.

PMID: 37996514

The features and management of acquired resistance to PD1-based therapy in metastatic melanoma.

Hepner A, Versluis JM, Wallace R, Allayous C, Brown LJ, Trojaniello C, Gerard CL, Jansen YJ, Bhave P, Neyns B, Haydon A, Michielin O, Mangana J, Klein O, Shoushtari AN, Warner AB, Ascierto PA, McQuade JL, Carlino MS, Zimmer L, Lebbe C, Johnson DB, Sandhu S, Atkinson V, Blank CU, Lo SN, Long GV, Menzies AM.

Eur J Cancer. 2024 Jan;196:113441. doi: 10.1016/j.ejca.2023.113441. Epub 2023 Nov 20.

PMID: 37988842

Immunosuppression is a conserved driver of tuberculosis susceptibility.

Kotov DI, Lee OV, Ji DX, Jaye DL, Suliman S, Gabay C, Vance RE.

bioRxiv. 2023 Nov 1:2023.10.27.564420. doi: 10.1101/2023.10.27.564420.

PMID: 37961447

The circadian clock time tunes axonal regeneration.

De Virgiliis F, Mueller F, Palmisano I, Chadwick JS, Luengo-Gutierrez L, Giarrizzo A, Yan Y, Danzi MC, Picon-Muñoz C, Zhou L, Kong G, Serger E, Hutson TH, Maldonado-Lasuncion I, Song Y, Scheiermann C, Brancaccio M, Di Giovanni S.

Cell Metab. 2023 Dec 5;35(12):2153-2164.e4. doi: 10.1016/j.cmet.2023.10.012. Epub 2023 Nov 10.

PMID: 37951214

Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.

Griffith JW, Faustino LD, Cottrell VI, Nepal K, Hariri LP, Chiu RS, Jones MC, Julé A, Gabay C, Luster AD.

Nat Immunol. 2023 Dec;24(12):2091-2107. doi: 10.1038/s41590-023-01655-2. Epub 2023 Nov 9.

PMID: 37945820

The European Society of Cardiology working group on atherosclerosis and vascular biology.

Lutgens E, Osto E, Bochaton-Piallat ML.

Eur Heart J. 2024 Jan 7;45(2):84-86. doi: 10.1093/eurheartj/ehad536.

PMID: 37944036

How to integrate CD19 specific chimeric antigen receptor T cells with other CD19 targeting agents in diffuse large B-cell lymphoma?

de Ramon Ortiz C, Wang S, Stathis A, Bertoni F, Zenz T, Novak U, Simonetta F.

Hematol Oncol. 2023 Nov 8. doi: 10.1002/hon.3237. 

PMID: 37937474 Review.

Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.

Abdelhak A, Benkert P, Schaedelin S, Boscardin WJ, Cordano C, Oechtering J, Ananth K, Granziera C, Melie-Garcia L, Montes SC, Beaudry-Richard A, Achtnichts L, Oertel FC, Lalive PH, Leppert D, Müller S, Henry RG, Pot C, Matthias A, Salmen A, Oksenberg JR, Disanto G, Zecca C, D'Souza M, Du Pasquier R, Bridel C, Gobbi C, Kappos L, Hauser SL, Cree BAC, Kuhle J, Green AJ; UCSF, MS EPIC, and the SMSC Study Teams.

JAMA Neurol. 2023 Dec 1;80(12):1317-1325. doi: 10.1001/jamaneurol.2023.3997.

PMID: 37930670

Dual targeting of H₂S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer.

Nafea H, Youness RA, Dawoud A, Khater N, Manie T, Abdel-Kader R, Bourquin C, Szabo C, Gad MZ.

Heliyon. 2023 Oct 17;9(10):e21063. doi: 10.1016/j.heliyon.2023.e21063. eCollection 2023 Oct.

PMID: 37916110

Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition.

Cardoso Dos Santos LM, Azar P, Brun C, König S, Roatti A, Baertschi AJ, Chaabane C, Bochaton-Piallat ML.

Sci Rep. 2023 Oct 31;13(1):18736. doi: 10.1038/s41598-023-45470-z.

PMID: 37907514 ree PMC article.

Enterococcus faecalis suppresses Staphylococcus aureus-induced NETosis and promotes bacterial survival in polymicrobial infections.

Kao PH, Ch'ng JH, Chong KKL, Stocks CJ, Wong SL, Kline KA.

FEMS Microbes. 2023 Oct 11;4:xtad019. doi: 10.1093/femsmc/xtad019. eCollection 2023.

PMID: 37900578

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion.

Franzi E, Mathez G, Dinant S, Deloizy C, Kaiser L, Tapparel C, Le Goffic R, Cagno V.

Int J Mol Sci. 2023 Oct 19;24(20):15382. doi: 10.3390/ijms242015382.

PMID: 37895062

A patatin-like phospholipase is important for mitochondrial function in malaria parasites.

Pietsch E, Ramaprasad A, Bielfeld S, Wohlfarter Y, Maco B, Niedermüller K, Wilcke L, Kloehn J, Keller MA, Soldati-Favre D, Blackman MJ, Gilberger T-W, Burda P-C.

mBio. 2023 Oct 26;14(6):e0171823. doi: 10.1128/mbio.01718-23. Online ahead of print.

PMID: 37882543

Detection of TPSAB1 copy number variation for the diagnosis of hereditary alpha-tryptasemia by quantitative PCR.

Docquier M, Nouspikel T, Blouin JL, Abramowicz M, Seebach JD, Spoerl D.

Clin Exp Allergy. 2023 Oct 18. doi: 10.1111/cea.14413. Online ahead of print.

PMID: 37853996

SwissParam 2023: A Modern Web-Based Tool for Efficient Small Molecule Parametrization.

Bugnon M, Goullieux M, Röhrig UF, Perez MAS, Daina A, Michielin O, Zoete V.

J Chem Inf Model. 2023 Nov 13;63(21):6469-6475. doi: 10.1021/acs.jcim.3c01053. Epub 2023 Oct 18.

PMID: 37853543

Serious infection risk of tofacitinib compared to biologics in patients with rheumatoid arthritis treated in routine clinical care.

Riek M, Scherer A, Möller B, Ciurea A, von Mühlenen I, Gabay C, Kyburz D, Brulhart L, von Kempis J, Mueller RB, Hasler P, Strahm T, von Känel S, Zufferey P, Dudler J, Finckh A.

Sci Rep. 2023 Oct 18;13(1):17776. doi: 10.1038/s41598-023-44841-w.

PMID: 37853058

Testing a Model of Care for Patients on Immune Checkpoint Inhibitors Based on Electronic Patient-Reported Outcomes: Protocol for a Randomized Phase II Controlled Trial.

da Silva Lopes AM, Colomer-Lahiguera S, Darnac C, Giacomini S, Bugeia S, Gutknecht G, Spurrier-Bernard G, Cuendet M, Muet F, Aedo-Lopez V, Mederos N, Michielin O, Addeo A, Latifyan S, Eicher M.

JMIR Res Protoc. 2023 Oct 18;12:e48386. doi: 10.2196/48386.

PMID: 37851498

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury.

Van Campenhout R, De Groof TWM, Kadam P, Kwak BR, Muyldermans S, Devoogdt N, Vinken M.

J Nanobiotechnology. 2023 Oct 11;21(1):371. doi: 10.1186/s12951-023-02137-1.

PMID: 37821897

Risk Factors for Dehiscence of Operative Incisions in Newborns after Laparotomy.

Miholjcic TBS, Baud O, Iranmanesh P, Wildhaber BE.

Eur J Pediatr Surg. 2023 Oct 10. doi: 10.1055/s-0043-1771223.

PMID: 37816380

Full-body blue light irradiation as treatment for atopic dermatitis: a randomized sham-controlled clinical trial (AD-Blue).

Buhl T, Santibanez Santana M, Forkel S, Kromer C, Seidel J, Möbs C, Pfützner W, Pfeiffer S, Laubach HJ, Boehncke WH, Liebmann J, Born M, Schön MP.

J Dtsch Dermatol Ges. 2023 Dec;21(12):1500-1510. doi: 10.1111/ddg.15211. Epub 2023 Oct 9.

PMID: 37814388 Clinical Trial.

Longitudinal associations between body mass index and changes in disease activity and radiographic progression in rheumatoid arthritis patients treated with infliximab.

Burkard T, Vallejo-Yagüe E, Lauper K, Finckh A, Hügle T, Burden AM.

RMD Open. 2023 Oct;9(4):e003396. doi: 10.1136/rmdopen-2023-003396.

PMID: 37802600

Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites.

Criado Santos N, Bouvet S, Cruz Cobo M, Mandavit M, Bermont F, Castelbou C, Mansour F, Azam M, Giordano F, Nunes-Hasler P.

Commun Biol. 2023 Oct 4;6(1):1008. doi: 10.1038/s42003-023-05382-0.

PMID: 37794132

Malaria: moving beyond the search for magic bullets.

Levashina E, Soldati-Favre D, Waters AP, Frischknecht F, Rayner JC.

EMBO Mol Med. 2023 Nov 8;15(11):e18727. doi: 10.15252/emmm.202318727. Epub 2023 Oct 4.

PMID: 37789804

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy.

Marone R, Landmann E, Devaux A, Lepore R, Seyres D, Zuin J, Burgold T, Engdahl C, Capoferri G, Dell'Aglio A, Larrue C, Simonetta F, Rositzka J, Rhiel M, Andrieux G, Gallagher DN, Schröder MS, Wiederkehr A, Sinopoli A, Do Sacramento V, Haydn A, Garcia-Prat L, Divsalar C, Camus A, Xu L, Bordoli L, Schwede T, Porteus M, Tamburini J, Corn JE, Cathomen T, Cornu TI, Urlinger S, Jeker LT.

J Exp Med. 2023 Dec 4;220(12):e20231235. doi: 10.1084/jem.20231235. Epub 2023 Sep 29.

PMID: 37773046

Calcium storage in multivesicular endo-lysosome.

Scott CC, Wasnik V, Nunes-Hassler P, Demaurex N, Kruse K, Gruenberg J.

Phys Biol. 2023 Oct 17;20(6). doi: 10.1088/1478-3975/acfe6a.

PMID: 37769681

Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species.

Jung E, Kraimps A, Dittmann S, Griesser T, Costafrolaz J, Mattenberger Y, Jurt S, Viollier PH, Sander P, Sievers S, Gademann K.

Chembiochem. 2023 Dec 14;24(24):e202300570. doi: 10.1002/cbic.202300570. Epub 2023 Oct 9.

PMID: 37728121

Deciphering calcium signals in cells and tissues with tailored probes and models.

Demaurex N.

J Physiol. 2023 Oct;601(19):4179-4181. doi: 10.1113/JP285037. Epub 2023 Sep 16.

PMID: 37715737 No abstract available.

Dendritic cells as shepherds of T cell immunity in cancer.

Pittet MJ, Di Pilato M, Garris C, Mempel TR.

Immunity. 2023 Oct 10;56(10):2218-2230. doi: 10.1016/j.immuni.2023.08.014. Epub 2023 Sep 13.

PMID: 37708889 Review.

Novel targets for immune-checkpoint inhibition in cancer.

Borgeaud M, Sandoval J, Obeid M, Banna G, Michielin O, Addeo A, Friedlaender A.

Cancer Treat Rev. 2023 Nov;120:102614. doi: 10.1016/j.ctrv.2023.102614. Epub 2023 Aug 12.

PMID: 37603905 Review.

NOX family NADPH oxidases in mammals: Evolutionary conservation and isoform-defining sequences.

Nazari B, Jaquet V, Krause KH.

Redox Biol. 2023 Oct;66:102851. doi: 10.1016/j.redox.2023.102851. Epub 2023 Aug 12.

PMID: 37595375

State-of-the-Science of human papillomavirus vaccination in women with human immunodeficiency Virus: Summary of a scientific workshop.

Schuind AE, Rees H, Schiller J, Mugo N, Dull P, Barnabas R, Clifford GM, Liu G, Madhi SA, Morse RB, Moscicki AB, Palefsky JM, Plotkin S, Sierra MS, Slifka MK, Vorsters A, Kreimer AR, Didierlaurent AM.

Prev Med Rep. 2023 Jul 19;35:102331. doi: 10.1016/j.pmedr.2023.102331. eCollection 2023 Oct.

PMID: 37576844 Review.

Mitochondrial pannexin1 controls cardiac sensitivity to ischaemia/reperfusion injury.

Rusiecka OM, Molica F, Nielsen MS, Tollance A, Morel S, Frieden M, Chanson M, Boengler K, Kwak BR.

Cardiovasc Res. 2023 Oct 24;119(13):2342-2354. doi: 10.1093/cvr/cvad120.

PMID: 37556386

The potential role of the microbiota in prostate cancer pathogenesis and treatment.

Pernigoni N, Guo C, Gallagher L, Yuan W, Colucci M, Troiani M, Liu L, Maraccani L, Guccini I, Migliorini D, de Bono J, Alimonti A.

Nat Rev Urol. 2023 Dec;20(12):706-718. doi: 10.1038/s41585-023-00795-2. Epub 2023 Jul 25.

PMID: 37491512 Review.

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era.

Buhler S, Sollet ZC, Bettens F, Schäfer A, Ansari M, Ferrari-Lacraz S, Villard J.

HLA. 2023 Dec;102(6):720-730. doi: 10.1111/tan.15158. Epub 2023 Jul 18.

PMID: 37461808

The risk of secondary progressive multiple sclerosis is geographically determined but modifiable.

Sharmin S, Roos I, Simpson-Yap S, Malpas C, Sánchez MM, Ozakbas S, Horakova D, Havrdova EK, Patti F, Alroughani R, Izquierdo G, Eichau S, Boz C, Zakaria M, Onofrj M, Lugaresi A, Weinstock-Guttman B, Prat A, Girard M, Duquette P, Terzi M, Amato MP, Karabudak R, Grand'Maison F, Khoury SJ, Grammond P, Lechner-Scott J, Buzzard K, Skibina O, van der Walt A, Butzkueven H, Turkoglu R, Altintas A, Maimone D, Kermode A, Shalaby N, Pesch VV, Butler E, Sidhom Y, Gouider R, Mrabet S, Gerlach O, Soysal A, Barnett M, Kuhle J, Hughes S, Sa MJ, Hodgkinson S, Oreja-Guevara C, Ampapa R, Petersen T, Ramo-Tello C, Spitaleri D, McCombe P, Taylor B, Prevost J, Foschi M, Slee M, McGuigan C, Laureys G, Hijfte LV, de Gans K, Solaro C, Oh J, Macdonell R, Aguera-Morales E, Singhal B, Gray O, Garber J, Wijmeersch BV, Simu M, Castillo-Triviño T, Sanchez-Menoyo JL, Khurana D, Al-Asmi A, Al-Harbi T, Deri N, Fragoso Y, Lalive PH, Sinnige LGF, Shaw C, Shuey N, Csepany T, Sempere AP, Moore F, Decoo D, Willekens B, Gobbi C, Massey J, Hardy T, Parratt J, Kalincik T.

Brain. 2023 Nov 2;146(11):4633-4644. doi: 10.1093/brain/awad218.

PMID: 37369086

Clonal expansion of intra-epithelial T cells in breast cancer revealed by spatial transcriptomics.

Romanens L, Chaskar P, Marcone R, Ryser S, Tille JC, Genolet R, Heimgartner-Hu K, Heimgartner K, Moore JS, Liaudet N, Kaya G, Pittet MJ, Dietrich PY, Delorenzi M, Speiser DE, Harari A, Tsantoulis P, Labidi-Galy SI.

Int J Cancer. 2023 Nov 1;153(9):1568-1578. doi: 10.1002/ijc.34620. Epub 2023 Jun 12.

PMID: 37306359

Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient.

Anchisi S, Wolfer A, Bisig B, Missiglia E, Tiab A, Kamel EM, Michielin O, Coukos G, Homicsko K.

Cancer Biol Ther. 2023 Dec 31;24(1):2193116. doi: 10.1080/15384047.2023.2193116.

PMID: 36967525