KIS Project

KIS Project

Title	Characterization of knee instability after knee arthroplasty
Dates	CCER authorisation in July 2018
Principal investigator	Hermes Miozzari (UNIGE/HUG)
Other investigators	Xavier Gasparutto (K-Lab, UNIGE/HUG), Stéphane Armand (K-Lab, UNIGE/HUG), Alice Bonnefoy-Mazure (K-Lab, UNIGE/HUG), Michael Attias (HEDS), Lena Carcreff (K-Lab, UNIGE/HUG)
Institutional collaborations	Not applicable.
Funding	Fondation pour la recherché ostéo-articulaire
Keywords	Total Knee Arthroplasty; Gait Analysis; Knee instability; PROMs
Website	Not available.
Related articles	Coming soon.

Abstract
Osteoarthritis (OA) is the most prevalent joint disease and a major public health problem. It is rising due to longer life expectancy, rising obesity prevalence and trauma to joint due to repetitive movements. Total knee arthroplasty (TKA) is indicated in end-stage knee OA. It is very effective in reducing pain, improving functional abilities, and restoring knee biomechanics and stability. Nevertheless, despite many innovations in TKA implant design, about 20% of patients continues to report pain, functional limitations (including subjective knee instability), and/or dissatisfaction after TKA. More specifically, knee instability is recognized as one of the causes of TKA failure resulting in 10 to 20% of prosthesis revisions. Revisions present a heavy burden as it have a significant impact on the emotional level of patients, have a higher mortality rate compared to primary TKA and have a large impact on the financial costs. A better characterization and understanding of knee instability could improve primary TKA survival and diminish the revision burden.


The global objective of this study is to characterize and understand prosthetic knee instability in patients following TKA. Four specific objectives are considered:

• Characterize objectively knee instability one year after TKA
• Assess the relationships between the measured knee instability after TKA with the capacity and performance limitations one year after TKA.
• Identify potential predictive factors of knee instability one year after TKA 4. Evaluate the recovery of stability after TKA