The biology of metabolism in health and disease

The Coppari's laboratory has the following main aims:

• Identifying neuron-types and molecules underlying normal metabolic homeostasis;
•  Identifying neuron-types and molecules protecting against diet-induced metabolic imbalance;
•  Identifying neuron-types and molecules permitting life without insulin;
• Exploiting effect of dietary interventions to unveil cancer vulnerabilities.

The Coppari's laboratory possesses the following  expertise:

• Generation of genetically-engineered mice bearing neuron-type-restricted mutations;
•  Metabolic assessments, including glucose/insulin clamp in unrestrained and awake rodents;
• Dietary interventions affecting cancer biology in rodents.