Proteins belonging to the ESCRT complexes are known as membrane remodeling factors, which regulate events such as cytokinesis, virus budding and multivesicular endosome (MVE) formation. Specifically, CHMP proteins (ESCRT III complex) are known as the key proteins in membrane deformation processes.  However, in mammalian cells, the exact mechanism by which recruitment of the ESCRT proteins to biological membranes occurs is not clear.  In order to better understand the role of ESCRT proteins, I am working with mammalian cells and in vitro assays using ESCRT recombinant proteins. In addition, I am interested in finding new proteins and lipids which could facilitate the recruitment of ESCRT proteins to the endosomal membranes.