My project is focused on the role of tubulin C-terminal tail on microtubule properties. The C-terminal tail represents the main region of difference between tubulin isotypes and also the major side of tubulin Post-Translational Modification (PTM). To investigate that, I am working in collaboration with the EPFL on a new approach, The Semi-Synthetic Tubulin, in which a conserved tubulin core is purified and then fused to a synthetic C-terminal tail of interest.