- Resolution of the First Non-Racemic Diquats
Jérôme Vachon, Gérald Bernardinelli, Jérôme Lacour
Chem. Eur. J. 2010, 16, 2797-2805
Three tricyclic (8-membered ring) diquats were prepared and shown to be the first configurationally stable derivatives of their kind. Resolution was achieved using chiral hexacoordinated phosphorus BINPHAT and TRISPHAT anions. Noticeably, these derivatives are the first eight-membered ring derivatives with only three ring constraints to be ever resolved. This manuscript also reports the first procedure to remove TRISPHAT anions after a diastereomeric separation.
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