127. One-step Catalytic Asymmetric Synthesis of Configurationally Stable Tröger Bases
     Ankit Sharma, Laure Guénée, Jean-Valère Naubron, Jérôme Lacour
     Angew. Chem. Int. Ed. 2011, 50, 3677-3680

Configurationally-stable ethano-Tröger bases are prepared in a single step via the direct Rh(II)-catalyzed reaction of methano-Tröger bases and diazo esters. The process is general, enantiospecific (ee up to 99%), diastereoselective (with a new quaternary carbon center introduction, dr up to 49:1) and regioselective.

DOI: 10.1002/anie.201100134 

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