- Macrocyclization of Oxetane Building Blocks with Diazocarbonyl Derivatives under Rhodium(II) Catalysis
Diane Rix, Rafael Ballesteros-Garrido, Walid Zeghida, Céline Besnard, Jérôme Lacour
Angew. Chem. Int. Ed. 2011, 50, 7308-7311
Highly concentrated: The title reaction proceeds to afford a rare type of 15-membered polyether macrocycle in up to 84 % yield (R1=alkyl, alkoxy, O-allyl, OCH2CH2Ph; R2=alkyl, Ph; R3=H, Me, Et). This nontemplated macrocyclization is performed in a single pot under high concentration and precludes the usual polymerization.
open archive unige:16745