- One-Pot Multi-Component Synthesis and Solid State Structures of Functionally Rich Polyether Macrocycles
Mahesh Vishe, Radim Hrdina, Laure Guénée, Céline Besnard, Jérôme Lacour
Adv. Synth. Catal. 2013, 355, 3161-3169
[ See the Front Cover ]
Densely functionalized polyether macrocycles can be prepared in one pot in yields up to 60% by Rhodium(II)-catalyzed decomposition of methyl diazoacetate in the presence of a variety of substituted or unsaturated 5 and 6 membered ring cyclic ethers. A comprehensive analysis of the solid state conformations of the macrocyclic geometries is detailed as well as novel mechanistic insights about the multi-component condensation reaction.
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