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Publication 40  

  1. An Air-stable Cationic Iridium Hydride as a Highly Active and General Catalyst for the Isomerization of Terminal Epoxides
    Nicolas Humbert, Devendra J. Vyas, Céline Besnard, Clément Mazet*
    Chem. Commun. 2014, 50, 10592-10595

We describe the use of an air-stable iridium hydride catalyst for the isomerization of terminal epoxides into aldehydes with perfect regioselectivity. The system operates at low loadings of catalyst (0.5 mol%), is highly practical, scalable, and tolerates functional groups that would not be compatible with Lewis acids typically used in stoichiometric amounts. Evidence for a rare hydride mechanism are provided.

open archive unige:39470

Editor’s version DOI: 10.1039/C4CC05260A