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- “Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides”
E.P. Kündig, T.M. Seidel, Y.-X. Jia, G. Bernardinelli,
Angew. Chem. Int. Ed. 2007, 46, 8484-8487.
Bring on the big cats: New, C2-symmetric bulky N-heterocyclic carbene ligands bring major improvements in the palladium-catalyzed asymmetric intramolecular α-arylation of amides to give oxindoles (see picture, dba=trans,trans-dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.
DOI : 10.1002/anie.200703408
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