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Publication 141
- “Oxindole Synthesis by direct coupling of C(sp2)—H and C(sp3)—H Centers”
Y.-X. Jia, E.P. Kündig,
Angew. Chem. Int. Ed. 2009, 48, 1636-1639.
[ Selectionné pour Synfacts 2009, 484]
An sp2/sp3 get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl Csp2—H and a Csp3—H center (see scheme, DMF=N,N-dimethylformamide).
DOI : 10.1002/anie.200805652
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