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Publication 157
- “Fused Indolines by Palladium-Catalyzed Asymmetric C—C Coupling Involving an Unactivated Methylene Group”
M. Nakanishi, D. Katayev, C. Besnard, E.P. Kündig,
Angew. Chem. Int. Ed. 2011, 50, 7438-7441.
[ Corrigendum: Angew. Chem. Int. Ed. 2011, 50, 9775]
Selectivity at high temperatures: Bulky, thermally stable, chiral palladium complexes generated from N-heterocyclic carbenes (NHCs; see picture) were successfully applied to the synthesis of highly enantioenriched trans-fused indolines. Remarkably, this reaction occurs at elevated temperatures with excellent asymmetric recognition of an enantiotopic C—H bond in an unactivated methylene unit.
DOI : 10.1002/anie.201102639
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