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Publication 84
- Total synthesis of (±)-Δ9(12)-capnellene via iterative intramolecular type-I-“Magnesium-ene” reactions
Oppolzer, W.; Bättig, K.
Tetrahedron Lett. 1982, 23, 4669-4672
The marine triquinane sesquiterpene Δ9(12)-capnellene (1) was synthesised from 2,2,5-trimethyl-5-hexenal (2) by a sequence of all synthetic operations in 5% overall yield. The key steps 3 → 4 → 5 → 6 involve two intramolecular type-I-“Mg-ene” processes.