97. Tris(2,4,6-trimethoxyphenyl)methyl Carbenium Ion for Charge Derivatization of Amines and Amino Acids
    Chagit Denekamp, Jérôme Lacour, Benoît Laleu, Emilia Rabkin
    J. Mass Spectrom. 2008, 43, 623-627

Primary and secondary alkyl amines substitute readily one of the para-methoxy substituents of tris(2,4,6-trimethoxyphenyl)methyl carbenium ion. With this rapid process, the preparation of permanently charged positive derivatives of amines, amino acids and small C-protected peptides is achieved. This is utilized here to facilitate the matrix assisted laser desorption ionization-time-of-flight (MALDI-TOF) analysis of these compounds.

DOI : 10.1002/jms.1360 

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