151. Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules
     K. T. Kim, S. Angerani, D. Chang, N. Winssinger
     J. Am. Chem. Soc. 2019, 141, 16288-16295

DNA-based circuitry empowers logic gated operations and amplifications but are restricted to a nucleic acid output. Templated reactions enable the translation of a nucleic acid cues into diverse small molecule outputs but are more limited in their amplification. Herein, we demonstrate the coupling of a DNA circuit to templated reactions in order to achieve high levels of amplification in the output of small molecules, in response to a nucleic acid input. We demonstrate that the coupling of the DNA circuit to templated reactions allow for the detection of fM concentration of analyte and can respond with the release of a cytotoxic drug.

DOI : 10.1021/jacs.9b05688 

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