30. Applications of laser-polarized ¹²⁹xe to biomolecular assays
    T. J. Lowery, S. M. Rubin, E. J. Ruiz, M. M. Spence, N. Winssinger, P. G. Schultz, A. Pines, D. E. Wemmer
    Magn. Reson. Imaging 2003, 21, 1235-1239

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized ¹²⁹Xe have motivated the application of ¹²⁹Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized ¹²⁹Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized ¹²⁹Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging.

DOI : 10.1016/j.mri.2003.08.025 

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