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Publication 39
- Concise Synthesis of Pochonin A, an HSP90 Inhibitor
E. Moulin, S. Barluenga, N. Winssinger
Org. Lett. 2005, 7, 5637-5639
An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.
DOI : 10.1021/ol052263+
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