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Publication 62
- DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV
K. Gorska, K.-T. Huang, O. Chaloin, N. Winssinger
Angew. Chem. Int. Ed. 2009, 48, 7695-7700
All under control: The programmability of hybridization has been utilized to generate a combinatorial library of structures that emulate the topologies of complex carbohydrates interacting with an antibody that shows broad-spectrum activity against HIV. This simple method involves attaching oligosaccharides tagged with peptide nucleic acids onto DNA templates in a controlled manner
DOI : 10.1002/anie.200903328
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