67. Clickable peptide nucleic acids (cPNA) with tunable affinity
    D. Chouikhi, S. Barluenga, N. Winssinger
    Chem. Commun. 2010, 46, 5476-5478

Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a "click" cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments.

DOI : 10.1039/C0CC01081B 

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