89. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries
    J.-P. Daguer, M. Ciobanu, S. Barluenga, N. Winssinger
    Org. Biomol. Chem. 2012, 10, 1502-1505

Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.

DOI : 10.1039/c2ob06880j 

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