110. A. Alexakis, R. Sedrani, N. Lensen, P. Mangeney,
     “Chiral aminal templates. Diastereo- and enantioselectivity in 1,4 (conjugate) and 1,2 additions with organometallic reagents”
     in Organic Synthesis via Organometallics; D. Enders, H.-J. Gais, W. Keim (Eds.)Vieweg: Wiesbaden, 1993; p. 1-9.

Chiral diamines, with a C2 axis of symmetry, form very easily aminals. These aminals act as very efficient chiral controller on both 1,4 (conjugate) and 1,2 additions to prochiral substrates. Steric control or chelation control may account of the high diastereoselectivity observed in these reactions, according to the organometallic reagent and to the solvent.

DOI : 10.1007/978-3-322-84062-2_1 

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