247. C. Hawner, K. Li, V. Cirriez, A. Alexakis,
     “Copper-catalysed asymmetric conjugate addition of aryl aluminium reaggents to trisubstituted enones: construction of aryl-substituted quaternary centers”
     Angew. Chem. Int. Ed. 2008, 47, 8211-8214.

Al be back: Novel aryl and alkenyl aluminum reagents are generated through a halogen/Li exchange–Li/Al transmetalation sequence. These aryl alanes are used in the copper-catalyzed asymmetric conjugate addition reaction to a variety of cyclic enones giving chiral aryl-substituted quaternary centers (see scheme). Both, electron-donating and electron-withdrawing groups give full conversion and very good ee values.

DOI : 10.1002/anie.200803436 

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