267. C. Ladjel, N. Fuchs, L. Gremaud, A. Alexakis,
     “Copper catalysed kinetic resolution of cyclic alkenyl cyclopropane malonate with organoaluminiun and grignard reaggents”
     Synlett 2010, 317-320.

We report herein the first copper-catalysed kinetic resolution of alkenyl cyclopropane malonates with organoaluminium and Grignard reagents. The conjugate products were exclusively obtained on five- and six-membered-ring substrates. After optimization of the reaction conditions, we observed good conversions and enantiomeric excesses using ferrocene-based ligands on five-membered-ring substrates, and phosphoramidite ligands on six-membered rings.

DOI : 10.1055/s-0029-1219171 

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