270. L. Palais, C. Bournaud, L. Micouin, A. Alexakis,
     “Copper-Catalysed Ring Opening of Polycyclic meso-Hydrazines with Trialkylaluminium Reagents and SimplePhos Ligands”
     Chem. Eur. J. 2010, 16, 2567-2573.

meso-Hydrazines could be desymmetrised by ring-opening reactions by using various metal catalysts to form substituted cyclopentenes, which have a high synthetic potential. Herein, we report the asymmetric copper-catalysed ring opening of a range of polycyclic hydrazines with trialkylaluminium reagents and SimplePhos ligands with both high isolated yields and enantioselectivities of up to 95 %.

DOI : 10.1002/chem.200902417 

archive ouverte unige:5287