279. C. Bournaud, E. Marchal, A. Quintard, S. Sulzer-Mossé, A. Alexakis,
     “Organocatalyst-mediated enantioselective intramolecular Michael addition of aldehydes to vinyl sulfones”
     Tetrahedron: Asymmetry 2010, 21, 1666-1673.

Chiral amines with a hydrogen bond donor promote the intramolecular conjugate addition of aldehydes to vinyl sulfones. Chiral cyclic sulfone-aldehydes are obtained in good yields with an ee of up to 82%.

DOI : 10.1016/j.tetasy.2010.03.043 

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