298. H. Li, A. Alexakis,
     “Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation”
     Angew. Chem. Int. Ed. 2012, 51, 1055-1058.

A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.

DOI : 10.1002/anie.201107129 

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