323. F. Giacomina, A. Alexakis,
     “Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis”
     Eur. J. Org. Chem. 2013, 6710-6721.

A new approach to highly enantioenriched cyclic compounds (up to 98 % ee) has been developed by using ω-ethylenic allylic substrates in a one-pot asymmetric allylic alkylation and ring-closing metathesis sequence. The starting compounds are synthetic equivalents of cyclic allylic substrates. The method is exemplified with both Cu and Ir catalysts, and chiral phosphoramidite ligands.

DOI : 10.1002/ejoc.201300971 

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