Département de chimie organique Département de chimie organique

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  1. D. Grassi, A. Alexakis,
    “Copper-Free Asymmetric Allylic Alkylation of Trisubstituted Cyclic Allyl Bromides Using Grignard Reagents”
    Angew. Chem. Int. Ed. 2013, 52, 13642-13646.

AAA: The asymmetric allylic alkylation (AAA) of trisubstituted cyclic allyl bromides with Grignard reagents is catalytic (2 mol % of ligand) and regioselective (SN2’/SN2=91:9→100:0). The quaternary carbon centers are formed with good to high enantioselectivity (e.r.=81.5:19.5→96:4).

DOI : 10.1002/anie.201307591 

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