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D. Willcox, S. Woodward, A. Alexakis,
“Enantioselective 1,4-additions of ClMeAl(CH=CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones”
Chem. Commun. 2014, 50, 1655-1657.
![](/sciences/chimie/pubGA/ga_2295.gif)
Chloromethylvinyl alanes (E)-ClMeAl(CH=CHR) prepared directly from terminal alkynes undergo 1,4-addition to cyclohexenone and 3-methylcyclohexenone in moderate to good yield (30–70%) and good to excellent stereoselectivity (80–98% ee) using readily available copper(I) sources and chiral ligands.
DOI : 10.1039/c3cc48191c
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