344. J. Graff, E. Łastawiecka, L. Guénée, F. Leroux, A. Alexakis,
     “Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands”
     Adv. Synth. Catal. 2015, 357, 2833-2839.

The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields.

DOI : 10.1002/adsc.201500323 

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