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Publication 60  


  1. A. Alexakis, J. Berlan, Y. Besace,
    “Organocopper conjugate addition reaction in the presence of trimethylchlorosilane”
    Tetrahedron Lett. 1986, 27, 1047-1050.

In the presence of TMSCl, the conjugate addition of organocuprates to various α, β-unsaturated esters, amides, ketones and nitriles is greatly improved. The reaction is faster, the yields are very high and the reaction is very clean.

DOI : 10.1016/S0040-4039(86)80044-2 

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