243. Selective Synthesis of Tetrahydro Oxepines by Cu-Catalyzed Condensations of Diazomalonates and gem-Dialkyl Vinyl Oxetanes
     Claire Montagnon, Romain Pertschi, Céline Besnard, Jérôme Lacour
     Adv. Synth. Catal. 2024, 366, 1070-1077

Thanks to an unprecedented gem-dialkyl substituent effect, an efficient synthesis of tetrahydro oxepine derivatives is achieved by ring expansion of vinyl oxetanes using acceptor (acceptor) diazo reagents under Cu(II)-catalysis. A large scope of 2-vinyl oxetanes and either diazo mono or diester reagents give access to a series of functionalized oxepines.

This manuscript was highlighted in Synfacts

DOI : 10.1002/adsc.202301399 

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