244. General Ir-Catalyzed N–H Insertions of Diazomalonates into Aliphatic and Aromatic Amines
     Zhuang Zhong, Céline Besnard, Jérôme Lacour
     Org. Lett. 2024, 26, 983-987

A general N–H insertion reactivity of acceptor–acceptor diazo malonate reagents is reported using [Ir(cod)Cl]₂ as catalyst. A large range of amines, primary and secondary, aliphatic and aromatic, is possible. Mild temperatures, perfect substrate/reactant stoichiometry, and good functional group compatibility render the process particularly attractive for the (late-stage) functionalization of amines.

DOI : 10.1021/acs.orglett.3c03929 

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