The economic and environmental benefits associated with the development of multistep ‘one-pot’ catalytic reactions have raised strong interest in academia and industry. The field emulates from Nature's ability to separate different reactive sites within an enzyme, or different enzymes within a cell to accomplish a series of orthogonal transformations in a given sequence without the need to isolate reactive intermediates.
In this context, we and other research groups have associated olefin isomerization with (at least) one additional chemical transformation using transition metal catalysts, organocatalysts, enzymatic catalysts or any combination thereof. In such ventures, a major task for the synthetic chemist is to meet the requirements of temporal resolution and compatibility of all reaction components to a single set of experimental conditions. Importantly, the elaboration of multicatalytic systems is not achieved at the expense of molecular complexity; rather it provides access to novel chemical space by exploiting the reactivity of a transiently generated (sensitive) functional group.