240. R. Millet, A. Alexakis,
     “Simplephos as efficient ligands for the copper-catalysed kinetic resolution of cyclic vinyloxiranes with grognard reaggents”
     Synlett 2008, 12, 1797-1800.

Cyclic vinyloxiranes react with Grignard reagents under copper catalysis. Highly efficient kinetic resolution is achieved with the new SimplePhos family of chiral phosphorus ligands. Stereodivergence could be exploited to get either the S_N2 or S_N2′ product with up to 96% ee.

DOI : 10.1055/s-2008-1077901 

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