241. C.A. Falciola, A. Alexakis,
     “Copper-Catalyzed Asymmetric Allylic Alkylation”
     Eur. J. Org. Chem. 2008, 3765-3780.

Over the past decade, much effort has been put on designing efficient chiral ligands and screening of the different parameters that govern the main challenges of asymmetric S_N2′ reactions, namely chemo-, regio- and enantioselectivity. This review traces the evolution of the methodologies for creating stereogenic centers through asymmetric copper-catalyzed allylic alkylation with the use of different organometallic reagents and their subsequent applications.

DOI : 10.1002/ejoc.200800025 

archive ouverte unige:8233