334. N. Germain, D. Schlaefli, M. Chellat, S. Rosset, A. Alexakis,
     “Domino Asymmetric Conjugate Addition-Conjugate Addition”
     Org. Lett. 2014, 16, 2006-2009.

Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.

DOI : 10.1021/ol5005752 

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