335. D. Grassi, A. Alexakis,
     “Transition metal-free asymmetric and diastereoselective allylic alkylation using Grignard reagents: construction of vicinal stereogenic centers via kinetic resolution”
     Chem. Sci. 2014, 5, 3803-3807.

The first transition metal-free diastereoselective and enantioselective asymmetric allylic alkylation (AAA) has been disclosed leading to the construction of vicinal tertiary/quaternary centers via a kinetic resolution protocol starting from readily available starting materials. This procedure is chemically appealing since no consecutive AAA or stereoselective metal-catalyzed/chiral ligand AAAs are required to construct the two stereocenters.

DOI : 10.1039/C4SC01003E 

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